|
KMID : 0613820070170050694
|
|
Journal of Life Science
2007 Volume.17 No. 5 p.694 ~ p.698
|
|
|
Effects of Berberine on Lymphocyte Proliferation and GM-CSF Production in Mice
|
|
Kim Eun-Young
Rho Min-Hee
Chung Yang-Sook
Kim Hyung-Soo
Kim Kwang-Hyuk
|
|
|
Abstract
|
|
|
|
Berberine, an alkaloid initially isolated from chinese herbal medicine, has antibiotic activities against a variety of organisms including bacteria, viruses, fungi, protozoans, and chlamydia. Furthermore, berberine has shown a number of beneficial effects, including anti-tumor, anti-inflammation, and vasodilatory effects. In this work we have investigated the effects of berberine on lymphocyte proliferation and GM-CSF production in mice. Mouse splenocytes were incubated with berberine and concanavalin A (Con A) to observe the effects on cell proliferation. The culture supernatants of splenocytes exposed to berberine, berberine plus LPS, and berberine plus Con A were harvested to assay GM-CSF. The cell proliferation of mice splenocytes exposed to berberine only (1 ㎍/㎖) was increased significantly more than PBS (control) group. But the Con A-induced cell growth was inhibited by berberine. The GM-CSF production from mice splenocyte culture exposed to berberine only was increased in comparison with PBS (control) group, but the production of it with LPS or Con A was inhibited by berbeline. The present findings may explain lympocyte proliferating and regulating effects of berberine.
|
|
|
KEYWORD
|
|
|
berberine, lymphocyte proliferation, GM-CSF
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|